Gene-specific Copy Number Variation Probe-XBP1
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| Catalog: |
CNVFP-XBP1-22997 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (XBP1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
XBP1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to XBP1 genes. This product achieves the purpose of detection by hybridizing with the XBP1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
X-box Binding Protein 1 |
| Gene Summary [Provided by RefSeq] |
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
XBP1 |
| Location |
22q12 |
| Chromosome |
Chromosome22 |
| Coordinates |
This gene maps to 29190547-29196560 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-XBP1-22997-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-XBP1-22997-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-XBP1-22997-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-XBP1-22997-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-XBP1-22997-AQ |
467nm |
418nm |
|
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