Naked DNA/Biomarker RNA Biodistribution Analysis

Major challenges for effective gene therapy include the safety and efficiency of gene transfer. Although viral vectors are very efficient for gene transfer, their use is still limited by safety concerns. For clinical applications, naked DNA is becoming more important due to its safety profile, easy preparation procedures, and moderate costs.

Creative Bioarray offers the RNA ISH assay to visualize and monitor the delivery and biodistribution of naked DNA to access the specificity and efficacy of these therapies. Our Naked DNA/Biomarker RNA Biodistribution Analysis services can help you validate and accelerate your gene therapy development.

RNA in situ hybridization (ISH) has various advantages in Naked DNA/Biomarker RNA Biodistribution Analysis:

• Detection of Naked DNA: RNA ISH assay enables the visualization of naked DNA. It provides the information of biodistribution and persistence of a naked DNA plasmid.
• Detection of Specific Gene Expression: RNA ISH assay enables the visualization of specific gene expression at the single cell level within the histological context.
• High Sensitivity and Specificity: It allows for very high sensitivity and specificity since it can detect single RNA molecules.
• Spatial Information: It provides spatial information about gene expression, demonstrating the exact location of the transcript within the cell and tissue.
• Versatility: This method can be applied to virtually any kind of tissue (fresh, frozen or paraffin-embedded), cell cultures and whole mount embryos.

Features of Naked DNA/Biomarker RNA Biodistribution Analysis

(1) Detect and identify cellular subtypes
(2) RNA molecule biomarker analysis
(3) Naked DNA analysis
(4) Custom probes designed within 1-2 weeks
(5) Fastest turnaround time

Benefits of Naked DNA/Biomarker RNA Biodistribution Analysis

(1) Detect and identify cellular subtypes
(2) Visualize gene regulation with morphological context
(3) Validate RNA biomarkers in intact tissues
(4) Assess naked DNA therapeutic delivery mechanism
(5) Evaluate biodistribution and efficacy of therapy
(6) Add a visual dimension to heterogeneous tissue biology and analysis

Creative Bioarray offers Naked DNA/Biomarker RNA Biodistribution Analysis for you as follows:

• Probe design
• Probe synthesis
• ISH staining
• Imaging
• Data analysis

Quotation and ordering

Our customer service representatives are available 24hr a day! We thank you for considering Creative Bioarray as your Naked DNA/Biomarker RNA Biodistribution Analysis partner.

References

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