Gene-specific Copy Number Variation Probe-VHLL
Add to Cart
| Catalog: |
CNVFP-VHLL-22852 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (VHLL). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
VHLL Gene-specific copy number variation probes are mainly used to detect the copy number variation related to VHLL genes. This product achieves the purpose of detection by hybridizing with the VHLL gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
VHL Like |
| Gene Summary [Provided by RefSeq] |
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010] |
| Gene Symbol |
VHLL |
| Location |
1q22 |
| Chromosome |
Chromosome1 |
| Coordinates |
This gene maps to 156268414-156269428 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-VHLL-22852-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-VHLL-22852-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-VHLL-22852-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-VHLL-22852-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-VHLL-22852-AQ |
467nm |
418nm |
|
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