Gene-specific Copy Number Variation Probe-SMAD2
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| Catalog: |
CNVFP-SMAD2-19015 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (SMAD2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
SMAD2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to SMAD2 genes. This product achieves the purpose of detection by hybridizing with the SMAD2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
SMAD Family Member 2 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| Gene Symbol |
SMAD2 |
| Location |
18q21.1 |
| Chromosome |
Chromosome18 |
| Coordinates |
This gene maps to 45359465-45457515 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-SMAD2-19015-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-SMAD2-19015-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-SMAD2-19015-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-SMAD2-19015-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-SMAD2-19015-AQ |
467nm |
418nm |
|
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