Gene-specific Copy Number Variation Probe-PRKG1
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| Catalog: |
CNVFP-PRKG1-16277 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PRKG1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PRKG1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PRKG1 genes. This product achieves the purpose of detection by hybridizing with the PRKG1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Protein Kinase, CGMP-dependent, Type I |
| Gene Summary [Provided by RefSeq] |
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] |
| Gene Symbol |
PRKG1 |
| Location |
10q11.23-q21.1 |
| Chromosome |
Chromosome10 |
| Coordinates |
This gene maps to 52750910-54058110 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PRKG1-16277-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PRKG1-16277-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PRKG1-16277-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PRKG1-16277-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PRKG1-16277-AQ |
467nm |
418nm |
|
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