Gene-specific Copy Number Variation Probe-PRKAR1A
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| Catalog: |
CNVFP-PRKAR1A-16294 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PRKAR1A). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PRKAR1A Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PRKAR1A genes. This product achieves the purpose of detection by hybridizing with the PRKAR1A gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha |
| Gene Summary [Provided by RefSeq] |
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013] |
| Gene Symbol |
PRKAR1A |
| Location |
17q24.2 |
| Chromosome |
Chromosome17 |
| Coordinates |
This gene maps to 66508109-66528910 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PRKAR1A-16294-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PRKAR1A-16294-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PRKAR1A-16294-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PRKAR1A-16294-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PRKAR1A-16294-AQ |
467nm |
418nm |
|
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