Gene-specific Copy Number Variation Probe-PPP1R12A
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| Catalog: |
CNVFP-PPP1R12A-16102 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PPP1R12A). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PPP1R12A Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PPP1R12A genes. This product achieves the purpose of detection by hybridizing with the PPP1R12A gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Protein Phosphatase 1 Regulatory Subunit 12A |
| Gene Summary [Provided by RefSeq] |
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
| Gene Symbol |
PPP1R12A |
| Location |
12q21.2-q21.31 |
| Chromosome |
Chromosome12 |
| Coordinates |
This gene maps to 80167342-80329235 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PPP1R12A-16102-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PPP1R12A-16102-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PPP1R12A-16102-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PPP1R12A-16102-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PPP1R12A-16102-AQ |
467nm |
418nm |
|
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