Gene-specific Copy Number Variation Probe-PPM1D
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| Catalog: |
CNVFP-PPM1D-16118 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PPM1D). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PPM1D Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PPM1D genes. This product achieves the purpose of detection by hybridizing with the PPM1D gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Protein Phosphatase, Mg2+/Mn2+ Dependent 1D |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
PPM1D |
| Location |
17q23.2 |
| Chromosome |
Chromosome17 |
| Coordinates |
This gene maps to 58677543-58743640 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PPM1D-16118-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PPM1D-16118-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PPM1D-16118-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PPM1D-16118-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PPM1D-16118-AQ |
467nm |
418nm |
|
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