Gene-specific Copy Number Variation Probe-PMS2
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| Catalog: |
CNVFP-PMS2-15933 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PMS2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PMS2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PMS2 genes. This product achieves the purpose of detection by hybridizing with the PMS2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
PMS1 Homolog 2, Mismatch Repair System Component |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016] |
| Gene Symbol |
PMS2 |
| Location |
7p22.1 |
| Chromosome |
Chromosome7 |
| Coordinates |
This gene maps to 6012869-6048737 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PMS2-15933-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PMS2-15933-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PMS2-15933-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PMS2-15933-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PMS2-15933-AQ |
467nm |
418nm |
|
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