Gene-specific Copy Number Variation Probe-PML
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| Catalog: |
CNVFP-PML-15939 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PML). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PML Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PML genes. This product achieves the purpose of detection by hybridizing with the PML gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Promyelocytic Leukemia |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
PML |
| Location |
15q24.1 |
| Chromosome |
Chromosome15 |
| Coordinates |
This gene maps to 74287013-74340155 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PML-15939-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PML-15939-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PML-15939-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PML-15939-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PML-15939-AQ |
467nm |
418nm |
|
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