Gene-specific Copy Number Variation Probe-PLEKHM2
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| Catalog: |
CNVFP-PLEKHM2-16006 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PLEKHM2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PLEKHM2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PLEKHM2 genes. This product achieves the purpose of detection by hybridizing with the PLEKHM2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Pleckstrin Homology And RUN Domain Containing M2 |
| Gene Summary [Provided by RefSeq] |
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017] |
| Gene Symbol |
PLEKHM2 |
| Location |
1p36.21 |
| Chromosome |
Chromosome1 |
| Coordinates |
This gene maps to 16010826-16061264 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PLEKHM2-16006-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PLEKHM2-16006-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PLEKHM2-16006-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PLEKHM2-16006-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PLEKHM2-16006-AQ |
467nm |
418nm |
|
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