Gene-specific Copy Number Variation Probe-NPC1L1
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| Catalog: |
CNVFP-NPC1L1-14506 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (NPC1L1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
NPC1L1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to NPC1L1 genes. This product achieves the purpose of detection by hybridizing with the NPC1L1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
NPC1 Like Intracellular Cholesterol Transporter 1 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| Gene Symbol |
NPC1L1 |
| Location |
7p13 |
| Chromosome |
Chromosome7 |
| Coordinates |
This gene maps to 44552134-44580914 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-NPC1L1-14506-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-NPC1L1-14506-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-NPC1L1-14506-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-NPC1L1-14506-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-NPC1L1-14506-AQ |
467nm |
418nm |
|
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