Gene-specific Copy Number Variation Probe-NLRP3
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| Catalog: |
CNVFP-NLRP3-14279 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (NLRP3). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
NLRP3 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to NLRP3 genes. This product achieves the purpose of detection by hybridizing with the NLRP3 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
NLR Family Pyrin Domain Containing 3 |
| Gene Summary [Provided by RefSeq] |
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] |
| Gene Symbol |
NLRP3 |
| Location |
1q44 |
| Chromosome |
Chromosome1 |
| Coordinates |
This gene maps to 247579457-247612406 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-NLRP3-14279-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-NLRP3-14279-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-NLRP3-14279-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-NLRP3-14279-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-NLRP3-14279-AQ |
467nm |
418nm |
|
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