Gene-specific Copy Number Variation Probe-NISCH
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| Catalog: |
CNVFP-NISCH-14328 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (NISCH). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
NISCH Gene-specific copy number variation probes are mainly used to detect the copy number variation related to NISCH genes. This product achieves the purpose of detection by hybridizing with the NISCH gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Nischarin |
| Gene Summary [Provided by RefSeq] |
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013] |
| Gene Symbol |
NISCH |
| Location |
3p21.1 |
| Chromosome |
Chromosome3 |
| Coordinates |
This gene maps to 52489523-52527088 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-NISCH-14328-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-NISCH-14328-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-NISCH-14328-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-NISCH-14328-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-NISCH-14328-AQ |
467nm |
418nm |
|
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