Gene-specific Copy Number Variation Probe-MAP3K4
Add to Cart
| Catalog: |
CNVFP-MAP3K4-10861 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (MAP3K4). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
MAP3K4 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to MAP3K4 genes. This product achieves the purpose of detection by hybridizing with the MAP3K4 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Mitogen-activated Protein Kinase Kinase Kinase 4 |
| Gene Summary [Provided by RefSeq] |
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014] |
| Gene Symbol |
MAP3K4 |
| Location |
6q26 |
| Chromosome |
Chromosome6 |
| Coordinates |
This gene maps to 161412821-161538417 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-MAP3K4-10861-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-MAP3K4-10861-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-MAP3K4-10861-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-MAP3K4-10861-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-MAP3K4-10861-AQ |
467nm |
418nm |
|
Other Products
