Gene-specific Copy Number Variation Probe-LRTOMT
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| Catalog: |
CNVFP-LRTOMT-10695 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (LRTOMT). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
LRTOMT Gene-specific copy number variation probes are mainly used to detect the copy number variation related to LRTOMT genes. This product achieves the purpose of detection by hybridizing with the LRTOMT gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Leucine Rich Transmembrane And O-methyltransferase Domain Containing |
| Gene Summary [Provided by RefSeq] |
This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017] |
| Gene Symbol |
LRTOMT |
| Location |
11q13.4 |
| Chromosome |
Chromosome11 |
| Coordinates |
This gene maps to 71791376-71821828 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-LRTOMT-10695-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-LRTOMT-10695-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-LRTOMT-10695-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-LRTOMT-10695-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-LRTOMT-10695-AQ |
467nm |
418nm |
|
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