Gene-specific Copy Number Variation Probe-LRP2
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| Catalog: |
CNVFP-LRP2-10447 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (LRP2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
LRP2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to LRP2 genes. This product achieves the purpose of detection by hybridizing with the LRP2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
LDL Receptor Related Protein 2 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009] |
| Gene Symbol |
LRP2 |
| Location |
2q31.1 |
| Chromosome |
Chromosome2 |
| Coordinates |
This gene maps to 169983618-170219122 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-LRP2-10447-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-LRP2-10447-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-LRP2-10447-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-LRP2-10447-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-LRP2-10447-AQ |
467nm |
418nm |
|
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