Gene-specific Copy Number Variation Probe-LIMK2
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| Catalog: |
CNVFP-LIMK2-08626 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (LIMK2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
LIMK2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to LIMK2 genes. This product achieves the purpose of detection by hybridizing with the LIMK2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
LIM Domain Kinase 2 |
| Gene Summary [Provided by RefSeq] |
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
LIMK2 |
| Location |
22q12.2 |
| Chromosome |
Chromosome22 |
| Coordinates |
This gene maps to 31608249-31676066 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-LIMK2-08626-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-LIMK2-08626-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-LIMK2-08626-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-LIMK2-08626-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-LIMK2-08626-AQ |
467nm |
418nm |
|
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