Gene-specific Copy Number Variation Probe-KCNQ1OT1
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| Catalog: |
CNVFP-KCNQ1OT1-07805 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (KCNQ1OT1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
KCNQ1OT1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to KCNQ1OT1 genes. This product achieves the purpose of detection by hybridizing with the KCNQ1OT1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
KCNQ1 Opposite Strand/antisense Transcript 1 (non-protein Coding) |
| Gene Summary [Provided by RefSeq] |
Human chromosomal region 11p15.5 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The human CDKN1C/KCNQ1OT1 domain is regulated by an ICR located in an intron of KCNQ1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the KCNQ1OT1 gene that is exclusively expressed from the paternal allele. The KCNQ1OT1 transcript is the antisense to the KCNQ1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. The transcript is abnormally expressed from both chromosomes in most patients with Beckwith-Wiedemann syndrome, and the transcript also plays an important role in colorectal carcinogenesis. [provided by RefSeq, Apr 2012] |
| Gene Symbol |
KCNQ1OT1 |
| Location |
11p15.5 |
| Chromosome |
Chromosome11 |
| Coordinates |
This gene maps to 2661767-2721228 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-KCNQ1OT1-07805-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-KCNQ1OT1-07805-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-KCNQ1OT1-07805-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-KCNQ1OT1-07805-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-KCNQ1OT1-07805-AQ |
467nm |
418nm |
|
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