Gene-specific Copy Number Variation Probe-HMGCR
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| Catalog: |
CNVFP-HMGCR-06751 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HMGCR). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HMGCR Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HMGCR genes. This product achieves the purpose of detection by hybridizing with the HMGCR gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
3-hydroxy-3-methylglutaryl-CoA Reductase |
| Gene Summary [Provided by RefSeq] |
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| Gene Symbol |
HMGCR |
| Location |
5q13.3 |
| Chromosome |
Chromosome5 |
| Coordinates |
This gene maps to 74632992-74657926 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HMGCR-06751-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HMGCR-06751-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HMGCR-06751-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HMGCR-06751-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HMGCR-06751-AQ |
467nm |
418nm |
|
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