Gene-specific Copy Number Variation Probe-HLA-DRB4
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| Catalog: |
CNVFP-HLA-DRB4-06789 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HLA-DRB4). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HLA-DRB4 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HLA-DRB4 genes. This product achieves the purpose of detection by hybridizing with the HLA-DRB4 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Major Histocompatibility Complex, Class II, DR Beta 4 |
| Gene Summary [Provided by RefSeq] |
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
HLA-DRB4 |
| Location |
6p21.3 |
| Chromosome |
Chromosome6_mcf_hap5 |
| Coordinates |
This gene maps to 3882323-3897292 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HLA-DRB4-06789-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HLA-DRB4-06789-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HLA-DRB4-06789-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HLA-DRB4-06789-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HLA-DRB4-06789-AQ |
467nm |
418nm |
|
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