Gene-specific Copy Number Variation Probe-HLA-DRB1
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| Catalog: |
CNVFP-HLA-DRB1-06791 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HLA-DRB1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HLA-DRB1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HLA-DRB1 genes. This product achieves the purpose of detection by hybridizing with the HLA-DRB1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Major Histocompatibility Complex, Class II, DR Beta 1 |
| Gene Summary [Provided by RefSeq] |
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
HLA-DRB1 |
| Location |
6p21.32 |
| Chromosome |
Chromosome6_ssto_hap7 |
| Coordinates |
This gene maps to 3850433-3993164 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HLA-DRB1-06791-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HLA-DRB1-06791-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HLA-DRB1-06791-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HLA-DRB1-06791-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HLA-DRB1-06791-AQ |
467nm |
418nm |
|
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