Gene-specific Copy Number Variation Probe-HLA-DQB1
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| Catalog: |
CNVFP-HLA-DQB1-06796 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HLA-DQB1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HLA-DQB1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HLA-DQB1 genes. This product achieves the purpose of detection by hybridizing with the HLA-DQB1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Major Histocompatibility Complex, Class II, DQ Beta 1 |
| Gene Summary [Provided by RefSeq] |
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| Gene Symbol |
HLA-DQB1 |
| Location |
6p21.32 |
| Chromosome |
Chromosome6_cox_hap2 |
| Coordinates |
This gene maps to 4072510-4080111 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HLA-DQB1-06796-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HLA-DQB1-06796-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HLA-DQB1-06796-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HLA-DQB1-06796-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HLA-DQB1-06796-AQ |
467nm |
418nm |
|
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