Gene-specific Copy Number Variation Probe-HLA-C
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| Catalog: |
CNVFP-HLA-C-06764 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HLA-C). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HLA-C Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HLA-C genes. This product achieves the purpose of detection by hybridizing with the HLA-C gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Major Histocompatibility Complex, Class I, C |
| Gene Summary [Provided by RefSeq] |
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008] |
| Gene Symbol |
HLA-C |
| Location |
6p21.33 |
| Chromosome |
Chromosome6 |
| Coordinates |
This gene maps to 31236525-31239913 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HLA-C-06764-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HLA-C-06764-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HLA-C-06764-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HLA-C-06764-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HLA-C-06764-AQ |
467nm |
418nm |
|
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