Gene-specific Copy Number Variation Probe-HECW2
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| Catalog: |
CNVFP-HECW2-06588 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (HECW2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
HECW2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to HECW2 genes. This product achieves the purpose of detection by hybridizing with the HECW2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2 |
| Gene Summary [Provided by RefSeq] |
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
| Gene Symbol |
HECW2 |
| Location |
2q32.3 |
| Chromosome |
Chromosome2 |
| Coordinates |
This gene maps to 197063976-197457335 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-HECW2-06588-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-HECW2-06588-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-HECW2-06588-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-HECW2-06588-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-HECW2-06588-AQ |
467nm |
418nm |
|
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