Gene-specific Copy Number Variation Probe-FURIN
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| Catalog: |
CNVFP-FURIN-05507 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (FURIN). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
FURIN Gene-specific copy number variation probes are mainly used to detect the copy number variation related to FURIN genes. This product achieves the purpose of detection by hybridizing with the FURIN gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Furin, Paired Basic Amino Acid Cleaving Enzyme |
| Gene Summary [Provided by RefSeq] |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Gene Symbol |
FURIN |
| Location |
15q26.1 |
| Chromosome |
Chromosome15 |
| Coordinates |
This gene maps to 91411884-91426687 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-FURIN-05507-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-FURIN-05507-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-FURIN-05507-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-FURIN-05507-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-FURIN-05507-AQ |
467nm |
418nm |
|
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