Gene-specific Copy Number Variation Probe-FIP1L1
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| Catalog: |
CNVFP-FIP1L1-05435 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (FIP1L1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
FIP1L1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to FIP1L1 genes. This product achieves the purpose of detection by hybridizing with the FIP1L1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Factor Interacting With PAPOLA And CPSF1 |
| Gene Summary [Provided by RefSeq] |
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
| Gene Symbol |
FIP1L1 |
| Location |
4q12 |
| Chromosome |
Chromosome4 |
| Coordinates |
This gene maps to 54243819-54326103 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-FIP1L1-05435-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-FIP1L1-05435-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-FIP1L1-05435-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-FIP1L1-05435-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-FIP1L1-05435-AQ |
467nm |
418nm |
|
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