Gene-specific Copy Number Variation Probe-FHOD3
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| Catalog: |
CNVFP-FHOD3-05448 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (FHOD3). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
FHOD3 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to FHOD3 genes. This product achieves the purpose of detection by hybridizing with the FHOD3 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Formin Homology 2 Domain Containing 3 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015] |
| Gene Symbol |
FHOD3 |
| Location |
18q12.2 |
| Chromosome |
Chromosome18 |
| Coordinates |
This gene maps to 33877701-34360018 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-FHOD3-05448-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-FHOD3-05448-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-FHOD3-05448-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-FHOD3-05448-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-FHOD3-05448-AQ |
467nm |
418nm |
|
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