Gene-specific Copy Number Variation Probe-DUT

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Catalog:	CNVFP-DUT-04274
Classification:	Copy Number Variation
Description:	Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (DUT). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services.
Application:	DUT Gene-specific copy number variation probes are mainly used to detect the copy number variation related to DUT genes. This product achieves the purpose of detection by hybridizing with the DUT gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	7-10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Name	Deoxyuridine Triphosphatase
Gene Summary [Provided by RefSeq]	This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Symbol	DUT
Location	15q21.1
Chromosome	Chromosome15
Coordinates	This gene maps to 48623620-48635570 in GRCh37 coordinates.
Species	Human

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