Gene-specific Copy Number Variation Probe-DLAT
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| Catalog: |
CNVFP-DLAT-03950 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (DLAT). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
DLAT Gene-specific copy number variation probes are mainly used to detect the copy number variation related to DLAT genes. This product achieves the purpose of detection by hybridizing with the DLAT gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Dihydrolipoamide S-acetyltransferase |
| Gene Summary [Provided by RefSeq] |
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009] |
| Gene Symbol |
DLAT |
| Location |
11q23.1 |
| Chromosome |
Chromosome11 |
| Coordinates |
This gene maps to 111895537-111935002 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-DLAT-03950-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-DLAT-03950-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-DLAT-03950-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-DLAT-03950-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-DLAT-03950-AQ |
467nm |
418nm |
|
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