Gene-specific Copy Number Variation Probe-DIO1
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| Catalog: |
CNVFP-DIO1-03977 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (DIO1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
DIO1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to DIO1 genes. This product achieves the purpose of detection by hybridizing with the DIO1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Iodothyronine Deiodinase 1 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016] |
| Gene Symbol |
DIO1 |
| Location |
1p32.3 |
| Chromosome |
Chromosome1 |
| Coordinates |
This gene maps to 54359860-54376759 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-DIO1-03977-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-DIO1-03977-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-DIO1-03977-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-DIO1-03977-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-DIO1-03977-AQ |
467nm |
418nm |
|
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