Gene-specific Copy Number Variation Probe-CRYAA
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| Catalog: |
CNVFP-CRYAA-03318 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CRYAA). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CRYAA Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CRYAA genes. This product achieves the purpose of detection by hybridizing with the CRYAA gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Crystallin Alpha A |
| Gene Summary [Provided by RefSeq] |
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014] |
| Gene Symbol |
CRYAA |
| Location |
21q22.3 |
| Chromosome |
Chromosome21 |
| Coordinates |
This gene maps to 44589140-44592913 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CRYAA-03318-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CRYAA-03318-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CRYAA-03318-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CRYAA-03318-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CRYAA-03318-AQ |
467nm |
418nm |
|
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