Gene-specific Copy Number Variation Probe-CLEC4M
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| Catalog: |
CNVFP-CLEC4M-02719 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CLEC4M). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CLEC4M Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CLEC4M genes. This product achieves the purpose of detection by hybridizing with the CLEC4M gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
C-type Lectin Domain Family 4 Member M |
| Gene Summary [Provided by RefSeq] |
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009] |
| Gene Symbol |
CLEC4M |
| Location |
19p13.2 |
| Chromosome |
Chromosome19 |
| Coordinates |
This gene maps to 7828034-7834491 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CLEC4M-02719-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CLEC4M-02719-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CLEC4M-02719-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CLEC4M-02719-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CLEC4M-02719-AQ |
467nm |
418nm |
|
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