Gene-specific Copy Number Variation Probe-CHRNA7
Add to Cart
| Catalog: |
CNVFP-CHRNA7-02830 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CHRNA7). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CHRNA7 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CHRNA7 genes. This product achieves the purpose of detection by hybridizing with the CHRNA7 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Cholinergic Receptor Nicotinic Alpha 7 Subunit |
| Gene Summary [Provided by RefSeq] |
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| Gene Symbol |
CHRNA7 |
| Location |
15q13.3 |
| Chromosome |
Chromosome15 |
| Coordinates |
This gene maps to 32322690-32462384 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CHRNA7-02830-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CHRNA7-02830-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CHRNA7-02830-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CHRNA7-02830-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CHRNA7-02830-AQ |
467nm |
418nm |
|
Other Products
