Gene-specific Copy Number Variation Probe-CHEK2
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| Catalog: |
CNVFP-CHEK2-02614 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CHEK2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CHEK2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CHEK2 genes. This product achieves the purpose of detection by hybridizing with the CHEK2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Checkpoint Kinase 2 |
| Gene Summary [Provided by RefSeq] |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| Gene Symbol |
CHEK2 |
| Location |
22q12.1 |
| Chromosome |
Chromosome22 |
| Coordinates |
This gene maps to 29083730-29137822 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CHEK2-02614-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CHEK2-02614-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CHEK2-02614-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CHEK2-02614-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CHEK2-02614-AQ |
467nm |
418nm |
|
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