Gene-specific Copy Number Variation Probe-CDKN2A
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| Catalog: |
CNVFP-CDKN2A-02548 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CDKN2A). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CDKN2A Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CDKN2A genes. This product achieves the purpose of detection by hybridizing with the CDKN2A gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Cyclin Dependent Kinase Inhibitor 2A |
| Gene Summary [Provided by RefSeq] |
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012] |
| Gene Symbol |
CDKN2A |
| Location |
9p21.3 |
| Chromosome |
Chromosome9 |
| Coordinates |
This gene maps to 21967750-21994490 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CDKN2A-02548-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CDKN2A-02548-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CDKN2A-02548-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CDKN2A-02548-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CDKN2A-02548-AQ |
467nm |
418nm |
|
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