Gene-specific Copy Number Variation Probe-CDK5R1
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| Catalog: |
CNVFP-CDK5R1-02532 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (CDK5R1). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
CDK5R1 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to CDK5R1 genes. This product achieves the purpose of detection by hybridizing with the CDK5R1 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Cyclin Dependent Kinase 5 Regulatory Subunit 1 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| Gene Symbol |
CDK5R1 |
| Location |
17q11.2 |
| Chromosome |
Chromosome17 |
| Coordinates |
This gene maps to 30814104-30818271 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-CDK5R1-02532-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-CDK5R1-02532-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-CDK5R1-02532-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-CDK5R1-02532-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-CDK5R1-02532-AQ |
467nm |
418nm |
|
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