Gene-specific Copy Number Variation Probe-APPL2
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Catalog: |
CNVFP-APPL2-00860 |
Classification: |
Copy Number Variation |
Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (APPL2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
Application: |
APPL2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to APPL2 genes. This product achieves the purpose of detection by hybridizing with the APPL2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
Category: |
Copy Number Variation |
Probe Kits Volume (µL): |
40 μL |
Quantity: |
20 Tests |
Hybridization Solution (µL): |
200 μL |
Turnaround Time: |
7-10 Business Days |
Shipping Time: |
1-2 Day Expedited Shipping |
Storage Conditions: |
Store at -20℃ and avoid light; |
Shipping Conditions: |
-20℃ |
Gene Details
Gene Name |
Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2 |
Gene Summary [Provided by RefSeq] |
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011] |
Gene Symbol |
APPL2 |
Location |
12q23.3 |
Chromosome |
Chromosome12 |
Coordinates |
This gene maps to 105567074-105630008 in GRCh37 coordinates. |
Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
1 |
OR
|
CNVFP-APPL2-00860-OR |
573nm |
548nm |
|
2 |
RE
|
CNVFP-APPL2-00860-RE |
599nm |
580nm |
|
3 |
GO
|
CNVFP-APPL2-00860-GO |
551nm |
525nm |
|
4 |
GR
|
CNVFP-APPL2-00860-GR |
515nm |
491nm |
|
5 |
AQ
|
CNVFP-APPL2-00860-AQ |
467nm |
418nm |
|
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