Gene-specific Copy Number Variation Probe-APC2
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| Catalog: |
CNVFP-APC2-00873 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (APC2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
APC2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to APC2 genes. This product achieves the purpose of detection by hybridizing with the APC2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
APC2, WNT Signaling Pathway Regulator |
| Gene Summary [Provided by RefSeq] |
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017] |
| Gene Symbol |
APC2 |
| Location |
19p13.3 |
| Chromosome |
Chromosome19 |
| Coordinates |
This gene maps to 1450147-1473243 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-APC2-00873-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-APC2-00873-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-APC2-00873-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-APC2-00873-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-APC2-00873-AQ |
467nm |
418nm |
|
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