Gene-specific Break Apart Probe-VEGFA

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Catalog:	GBAFP-VEGFA-18783
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (VEGFA). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	VEGFA Gene-specific Break Apart Probe is designed to detect potential VEGFA rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Vascular Endothelial Growth Factor A
Gene Summary [Provided by RefSeq]	This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Gene Symbol	VEGFA
Location	6p21.1
Chromosome	Chromosome6
Coordinates	This gene maps to 43737945-43754223 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-VEGFA-18783-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-VEGFA-18783-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-VEGFA-18783-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-VEGFA-18783-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-VEGFA-18783-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-VEGFA-18783-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-VEGFA-18783-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-VEGFA-18783-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-VEGFA-18783-REGR	599nm;515nm	580nm;491nm

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