Gene-specific Break Apart Probe-TTN

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Catalog:	GBAFP-TTN-08731
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (TTN). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	TTN Gene-specific Break Apart Probe is designed to detect potential TTN rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Titin
Gene Summary [Provided by RefSeq]	This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Gene Symbol	TTN
Location	2q31.2
Chromosome	Chromosome2
Coordinates	This gene maps to 179390717-179672150 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-TTN-08731-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-TTN-08731-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-TTN-08731-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-TTN-08731-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-TTN-08731-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-TTN-08731-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-TTN-08731-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-TTN-08731-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-TTN-08731-REGR	599nm;515nm	580nm;491nm

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