Gene-specific Break Apart Probe-TNNT3

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Catalog:	GBAFP-TNNT3-18247
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (TNNT3). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	TNNT3 Gene-specific Break Apart Probe is designed to detect potential TNNT3 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Troponin T3, Fast Skeletal Type
Gene Summary [Provided by RefSeq]	The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Gene Symbol	TNNT3
Location	11p15.5
Chromosome	Chromosome11
Coordinates	This gene maps to 1940798-1959936 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-TNNT3-18247-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-TNNT3-18247-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-TNNT3-18247-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-TNNT3-18247-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-TNNT3-18247-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-TNNT3-18247-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-TNNT3-18247-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-TNNT3-18247-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-TNNT3-18247-REGR	599nm;515nm	580nm;491nm

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