Gene-specific Break Apart Probe-TBC1D4

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Catalog:	GBAFP-TBC1D4-08138
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (TBC1D4). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	TBC1D4 Gene-specific Break Apart Probe is designed to detect potential TBC1D4 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	TBC1 Domain Family Member 4
Gene Summary [Provided by RefSeq]	This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Symbol	TBC1D4
Location	13q22.2
Chromosome	Chromosome13
Coordinates	This gene maps to 75858808-76056250 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-TBC1D4-08138-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-TBC1D4-08138-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-TBC1D4-08138-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-TBC1D4-08138-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-TBC1D4-08138-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-TBC1D4-08138-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-TBC1D4-08138-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-TBC1D4-08138-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-TBC1D4-08138-REGR	599nm;515nm	580nm;491nm

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