Gene-specific Break Apart Probe-SLC4A1

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Catalog:	GBAFP-SLC4A1-07608
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (SLC4A1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	SLC4A1 Gene-specific Break Apart Probe is designed to detect potential SLC4A1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Solute Carrier Family 4 Member 1 (Diego Blood Group)
Gene Summary [Provided by RefSeq]	The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]
Gene Symbol	SLC4A1
Location	17q21.31
Chromosome	Chromosome17
Coordinates	This gene maps to 42325757-42345502 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-SLC4A1-07608-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-SLC4A1-07608-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-SLC4A1-07608-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-SLC4A1-07608-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-SLC4A1-07608-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-SLC4A1-07608-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-SLC4A1-07608-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-SLC4A1-07608-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-SLC4A1-07608-REGR	599nm;515nm	580nm;491nm

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