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| Catalog: | GBAFP-SHC1-07304 |
| Classification: | Gene-specific Break Apart Probes |
| Description: | Our Gene-specific Break Apart Probes usually target the flanks of the target gene (SHC1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent. |
| Application: | SHC1 Gene-specific Break Apart Probe is designed to detect potential SHC1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services. |
| Quantity: | 20 Tests |
| Probe Kits Volume (µL): | 40 μL |
| Hybridization Solution (µL): | 200 μL |
| Turnaround Time: | Within 10 Business Days |
| Shipping Time: | 1-2 Day Expedited Shipping |
| Shipping Conditions: | -20℃ |
| Storage Conditions: | Store at -20℃ and avoid light; |
| Gene Name | SHC Adaptor Protein 1 |
| Gene Summary [Provided by RefSeq] | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| Gene Symbol | SHC1 |
| Location | 1q21.3 |
| Chromosome | Chromosome1 |
| Coordinates | This gene maps to 154934773-154946959 in GRCh37 coordinates. |
| Species | Human |
| Number | Dye Color | Order Name | Absorbance Maximum | Emission Maximum | Add to Cart |
| 1 | GR; OR | GBAFP-SHC1-07304-GROR | 515nm;573nm | 491nm;548nm | |
| 2 | AQ; OR | GBAFP-SHC1-07304-AQOR | 467nm;573nm | 418nm;548nm | |
| 3 | GO; GR | GBAFP-SHC1-07304-GOGR | 551nm;515nm | 525nm;491nm | |
| 4 | GO; RE | GBAFP-SHC1-07304-GORE | 551nm;599nm | 525nm;580nm | |
| 5 | GR; GO | GBAFP-SHC1-07304-GRGO | 515nm;551nm | 491nm;525nm | |
| 6 | GR; RE | GBAFP-SHC1-07304-GRRE | 515nm;599nm | 491nm;580nm | |
| 7 | OR; GR | GBAFP-SHC1-07304-ORGR | 573nm;515nm | 548nm;491nm | |
| 8 | RE; GO | GBAFP-SHC1-07304-REGO | 599nm;551nm | 580nm;525nm | |
| 9 | RE; GR | GBAFP-SHC1-07304-REGR | 599nm;515nm | 580nm;491nm |
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