Gene-specific Break Apart Probe-ROBO3

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Catalog:	GBAFP-ROBO3-16654
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (ROBO3). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	ROBO3 Gene-specific Break Apart Probe is designed to detect potential ROBO3 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Roundabout Guidance Receptor 3
Gene Summary [Provided by RefSeq]	This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009]
Gene Symbol	ROBO3
Location	11q24.2
Chromosome	Chromosome11
Coordinates	This gene maps to 124735304-124751370 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-ROBO3-16654-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-ROBO3-16654-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-ROBO3-16654-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-ROBO3-16654-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-ROBO3-16654-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-ROBO3-16654-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-ROBO3-16654-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-ROBO3-16654-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-ROBO3-16654-REGR	599nm;515nm	580nm;491nm

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