Gene-specific Break Apart Probe-RAN

Add to Cart

Catalog:	GBAFP-RAN-16469
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (RAN). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	RAN Gene-specific Break Apart Probe is designed to detect potential RAN rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	RAN, Member RAS Oncogene Family
Gene Summary [Provided by RefSeq]	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Gene Symbol	RAN
Location	12q24.33
Chromosome	Chromosome12
Coordinates	This gene maps to 131356616-131360826 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-RAN-16469-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-RAN-16469-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-RAN-16469-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-RAN-16469-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-RAN-16469-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-RAN-16469-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-RAN-16469-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-RAN-16469-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-RAN-16469-REGR	599nm;515nm	580nm;491nm

Other Products

Products

CONTACT SUPPORT

Online Inquiry