Gene-specific Break Apart Probe-PTRH2

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Catalog:	GBAFP-PTRH2-06616
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (PTRH2). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	PTRH2 Gene-specific Break Apart Probe is designed to detect potential PTRH2 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Peptidyl-tRNA Hydrolase 2
Gene Summary [Provided by RefSeq]	The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Symbol	PTRH2
Location	17q23.1
Chromosome	Chromosome17
Coordinates	This gene maps to 57774666-57784856 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-PTRH2-06616-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-PTRH2-06616-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-PTRH2-06616-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-PTRH2-06616-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-PTRH2-06616-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-PTRH2-06616-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-PTRH2-06616-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-PTRH2-06616-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-PTRH2-06616-REGR	599nm;515nm	580nm;491nm

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