Gene-specific Break Apart Probe-POMC

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Catalog:	GBAFP-POMC-06278
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (POMC). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	POMC Gene-specific Break Apart Probe is designed to detect potential POMC rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Proopiomelanocortin
Gene Summary [Provided by RefSeq]	This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
Gene Symbol	POMC
Location	2p23.3
Chromosome	Chromosome2
Coordinates	This gene maps to 25383721-25391559 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-POMC-06278-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-POMC-06278-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-POMC-06278-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-POMC-06278-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-POMC-06278-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-POMC-06278-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-POMC-06278-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-POMC-06278-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-POMC-06278-REGR	599nm;515nm	580nm;491nm

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