Gene-specific Break Apart Probe-PIKFYVE

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Catalog:	GBAFP-PIKFYVE-15826
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (PIKFYVE). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	PIKFYVE Gene-specific Break Apart Probe is designed to detect potential PIKFYVE rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Phosphoinositide Kinase, FYVE-type Zinc Finger Containing
Gene Summary [Provided by RefSeq]	Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Gene Symbol	PIKFYVE
Location	2q34
Chromosome	Chromosome2
Coordinates	This gene maps to 209130990-209223475 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-PIKFYVE-15826-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-PIKFYVE-15826-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-PIKFYVE-15826-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-PIKFYVE-15826-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-PIKFYVE-15826-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-PIKFYVE-15826-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-PIKFYVE-15826-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-PIKFYVE-15826-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-PIKFYVE-15826-REGR	599nm;515nm	580nm;491nm

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